Ahhh... well two things: One, I wouldn't call your first example a "typical American comic"... one reason being, it's almost 70 years old (1940), and hardly anybody uses that look anymore unless they're being purposefully derivative. For another, it supposes that there's any such thing as "typical comics".
The other issue is that nobody really uses water colors or acrylics or markers, or anything like that, not any more. Some still do, and of course people will continue to do so, but pretty much the entire professional graphics industry (not just comics, but everyone who produces commercial illustrations) has converted to digital production, which means mostly what people use is Photoshop or Painter and a tablet device of one sort or another.
As far as I can tell, you're asking how to achieve blended colors, and the solution to that is to use tools that, well... blend colors. In the digital environment, one can set brushes to do all sorts of things, but I'd say one of the easier things to do is to set one's brush opacity to something like 40%-60%, and then to regularly pick out colors that blend between primaries as they're mixed by the semi-opaque brush passing over previous strokes.
Digital painting (indeed, painting as a whole) is no less a complex task than learning to draw in the first place. And just like drawing, the best solution is usually to start simple, make a lot of mistakes, learn from them and try again. It takes a while, but you get there eventually.